Huntingtin is a cell-autonomous regulator of neuropeptide trafficking and clock output
Agustina Bruno-Vignolo, Cayetana Arnaiz, Florencia Fernández-Chiappe…·Nara Ines Muraro
This study shows that wild-type Huntingtin regulates neuropeptide trafficking, neuronal excitability, and circadian rhythms in Drosophila, with loss of function causing sleep disturbances and disrupted vesicle dynamics.