BioengineeringbioRxivPreprint
Enhancing ML-based binder design with high-throughput screening: a comparison of mRNA and yeast display technologies
Zhiyuan Yao, McGuire Metts, Avery K. Huber…·Brian A. Kuhlman
This study compares mRNA and yeast display technologies for evaluating ML-designed miniprotein binders, finding mRNA display better enriches slow dissociating binders and achieves higher library coverage.