McGuire Metts

This paper designs de novo proteins that bind DELE1, block its oligomerization, and inhibit the mitochondrial stress response in cells.

This study compares mRNA and yeast display technologies for evaluating ML-designed miniprotein binders, finding mRNA display better enriches slow dissociating binders and achieves higher library coverage.

This study identifies a non-catalytic function of SETD2 in maintaining nuclear lamina stability and genome integrity through its N-terminus interactions.