BiochemistrybioRxiv
Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
J. A. Amrhein, L. M. Berger, D.-I. Balourdas…·T. Hanke
The paper designs and synthesizes a macrocyclic inhibitor, JA310, that selectively targets MST3 with high potency and kinome-wide selectivity.
DOI 10.1021/acs.jmedchem.3c01980