BiochemistrybioRxivPreprint
Low normal factor V enhances thrombin generation in hemophilia A through a substrate competition mechanism with factor Xa
D. M. Monroe, C. Baird, J. A. Peterson…·K. Neeves
The paper shows low normal factor V levels enhance thrombin generation in hemophilia A through reduced substrate competition with factor Xa for factor VIII activation.
DOI 10.1101/2022.06.27.496845