Cell BiologybioRxivPreprint
Lis1 relieves cytoplasmic dynein-1 auto-inhibition by acting as a molecular wedge
E. P. Karasmanis, J. M. Reimer, A. A. Kendrick…·A. E. Leschziner
The paper presents a structure showing Lis1 relieves dynein-1 auto-inhibition by acting as a molecular wedge, revealing its role in dynein activation.