J. A. Rodriguez

The paper identifies a nine-miRNA signature from plasma-derived exosomes to classify benign vs. malignant gastric diseases and detects 15 differentially expressed miRNAs across cancer stages.

This paper determines the cryo-EM structure of human LECT2 amyloid fibrils, revealing a tightly packed core stabilized by polar residues and hydrophobic contacts.

This study identifies an amyloidogenic segment in CPEB3's prion domain that is critical for its function in translational regulation and long-term memory.

The paper presents a structure showing Lis1 relieves dynein-1 auto-inhibition by acting as a molecular wedge, revealing its role in dynein activation.

The paper identifies Sfrp1 as an autocrine inhibitor of fibroblast invasion during lung fibrosis by analyzing fibroblast states and signaling pathways in mouse lung regeneration.

This paper introduces a fragment-based method for de novo structure determination of peptidic nanocrystals using MicroED, enabling the solution of previously intractable structures.

This paper introduces a method to determine atomic structures from digitally defined regions of nanocrystals using scanning nanobeam electron diffraction.

The paper identifies LUZP1 as a regulator of primary cilia and actin cytoskeleton, showing its role in Townes-Brocks Syndrome through interactions with SALL1 and effects on ciliogenesis and Sonic Hedgehog signaling.

The paper determines homochiral and racemic structures of a peptide from InaZ using MicroED, revealing amyloid-like protofibrils with distinct chiral arrangements.