A bacterial microbiome is dispensable for the induction of CD8 T cell exhaustion
M. Kuhlmann, D. D. C. Kolland, G. P. d. Almeida, C. Hoffmann, M. von Hoesslin, J. Berner, C. Wurmser, C. Ohnmacht, D. Zehn
This study shows that the microbiome is not required for T cell exhaustion in chronic LCMV infections, as germ-free mice exhibit similar exhaustion markers and gene expression patterns to specific pathogen-free mice.
bioRxiv · Oct 3, 2022Immunology