M. Prlic

50-color phenotyping of the human immune system with in-depth assessment of T cells and dendritic cells

The paper develops a 50-color flow cytometry panel for comprehensive immune cell phenotyping, including T cells and dendritic cells, and provides a 45-color version for broader use.

A non-invasive method to sample immune cells in the lower female genital tract using menstrual discs

This paper develops a non-invasive method using menstrual discs to sample immune cells from the female genital tract, demonstrating consistent T cell populations across days within individuals.

TGF-β broadly modifies rather than specifically suppresses reactivated memory CD8 T cells in a dose-dependent manner

This study shows TGF-β modifies rather than specifically suppresses reactivated memory CD8 T cells in a dose-dependent manner, affecting cytotoxicity and chemotactic properties.

Convergent clonal selection of donor- and recipient-derived CMV-specific T cells in hematopoietic stem cell transplant patients

The paper tracks T cell competition in CMV-reactivation post-transplant, finding donor-derived T cells expand but recipient-derived memory T cells remain dominant due to convergent clonal selection.

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8 T cells

The paper shows that inflammatory cytokines can increase TOX expression in human and mouse CD8 T cells, and that TOX is not required for PD-1 expression.

Cervicovaginal tissue residence imprints a distinct differentiation program upon memory CD8 T cells

The paper shows that residence in cervicovaginal tissue shapes CD8 T cell phenotype and function, leading to reduced local immunity and impaired viral control upon secondary challenge.

A targeted multi-omic analysis approach measures protein expression and low abundance transcripts on the single cell level

The paper introduces a targeted multi-omic approach that measures protein and low abundance transcript expression on single cells, requiring less sequencing depth than whole transcriptome methods.

Elimination of HSV-2 infected cells is mediated predominantly by paracrine effects of tissue-resident T cell derived cytokines

The paper shows HSV-2 is controlled by cytokines from tissue-resident T cells, not direct cell killing, even when T-cell numbers are low.

Anti-proliferative therapy for HIV cure: a compound interest approach

The paper uses a mathematical model to show that combining anti-proliferative therapies with ART can lead to a functional cure for HIV within 2-10 years instead of decades.