Author

J. Bhin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Jonkers· 3 shared C. Lieftink· 2 shared E. Gogola· 2 shared M. Paes Dias· 2 shared R. de Bruijn· 2 shared R. L. Beijersbergen· 2 shared S. Annunziato· 2 shared S. Rottenberg· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCancer Biology

J. Jonkers

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Author profile →

3 papers

Recent·Most cited

Multi-omics analysis reveals distinct non-reversion mechanisms of PARPi resistance in BRCA1- versus BRCA2-deficient mammary tumors

J. Bhin, M. Paes Dias, E. Gogola, F. Rolfs, S. R. Piersma, R. de Bruijn, J. de Ruiter, B. van den Broek, A. Duarte, W. Sol, I. van der Heijden, L. Bakker, T. S. Kaiponen, C. Lieftink, B. Morris, , J. Jonkers

bioRxiv · Sep 7, 2022Cancer Biology

Loss of Nuclear DNA Ligase III Reverts PARP Inhibitor Resistance in BRCA1/53BP1 Double-deficient Cells by Exposing ssDNA Gaps

M. Paes Dias, V. Tripathi, I. v. d. Heijden, K. Cong, E.-M. Manolika, J. Bhin, E. Gogola, P. Galanos, S. Annunziato, C. Lieftink, M. Andujar-Sanchez, S. Chakrabarty, G. C. M. Smith, M. v. d. Ven, R. L. Beijersbergen, , J. Jonkers

This study identifies loss of LIG3 as a factor that reverts PARP inhibitor resistance in BRCA1/53BP1 double-deficient cells by increasing ssDNA gaps.

bioRxiv · Mar 24, 2021 · PreprintCancer Biology

MYC promotes immune-suppression in TNBC via inhibition of IFN signaling

D. Zimmerli, C. S. Brambillasca, F. Talens, J. Bhin, A. Bhattacharya, S. E. P. Joosten, A. Moises da Silva, M. D. Wellenstein, K. Kersten, M. de Boo, M. Roorda, L. Henneman, R. de Bruijn, S. Annunziato, E. van der Burg, , J. Jonkers

This study shows MYC overexpression in TNBC reduces immune cell infiltration and interferon signaling, contributing to immune evasion and poor response to immunotherapy.

bioRxiv · Feb 24, 2021 · PreprintCancer Biology