Hippo Pathway Deregulation Drives Tissue Stiffness and Cancer Stem-like Cells in Lung Adenocarcinoma
D. Pankova, Y. Jiang, I. Vendrell, J. Buzzelli, A. J. Ryan, C. Brown, E. O'Neill
This study shows that epigenetic silencing of RASSF1A and increased P4HA2 activity drive tissue stiffness and cancer stem-like properties in lung adenocarcinoma, with potential therapeutic implications.
bioRxiv · Aug 13, 2018Cancer Biology