I. Vendrell

Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor

This study investigates the structural dynamics of USP30 inhibition by a covalent inhibitor, revealing its binding mechanism and selectivity advantages over non-covalent inhibitors.

SCF cyclin F - EXO1 axis controls cell cycle dependent execution of double strand break repair

The paper identifies SCF cyclin F's role in regulating EXO1 degradation to control cell cycle-dependent DSB repair pathways.

Proximity proteomics reveals UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution

This study shows that the order of FBXW7 and APC mutations affects colorectal cancer initiation, with FBXW7 mutations before APC preventing cancer-like features.

LARP1 regulates metabolism and mTORC1 activity in cancer

This study identifies LARP1 as a key regulator of metabolism and mTORC1 activity in cancer, showing its role in sustaining cellular metabolism and driving cancer progression.

Deep proteomics network and machine learning analysis of human cerebrospinal fluid in Japanese encephalitis virus infection

This study identifies a ten-protein diagnostic signature for Japanese encephalitis virus infection in cerebrospinal fluid with >99% accuracy using proteomics and machine learning.

USP18 is an essential regulator of muscle cell differentiation and maturation

This study identifies USP18 as a critical regulator of muscle cell differentiation and maturation, independent of its role in the ISG response.

RASSF1A Is Required For The Maintenance Of Nuclear Actin Levels

This study identifies RASSF1A as a regulator of nuclear actin levels by supporting exportin-6 binding to RAN GTPase, linking it to tumor suppression through MRTF/SRF regulation.

Cyclin F-Chk1 synthetic lethality mediated by E2F1 degradation

The paper identifies synthetic lethality between Chk1 inhibition and cyclin F loss, revealing Cyclin F's role in preventing DNA replication stress via E2F1 degradation.

SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication

This paper shows SPRTN protease and CHK1 form a cross-activation loop to protect DNA replication from stress by regulating CHK1 chromatin eviction and DPC removal.

Hippo Pathway Deregulation Drives Tissue Stiffness and Cancer Stem-like Cells in Lung Adenocarcinoma

This study shows that epigenetic silencing of RASSF1A and increased P4HA2 activity drive tissue stiffness and cancer stem-like properties in lung adenocarcinoma, with potential therapeutic implications.