C. Brown

FGF21 Analogue PF-05231023 on Alcohol Consumption and Neuronal Activity in the Nucleus Accumbens

This study evaluates the effects of PF-05231023, an FGF21 analogue, on alcohol consumption and neuronal activity in the nucleus accumbens, showing reduced intake and altered neural responses.

Behavioral and neural correlates of social hierarchy formation in a sex-changing fish

This study examines social hierarchy formation in sex-changing fish, finding that dominance is size-based and disruption leads to rapid behavioral and neural changes.

A diverse and distinct microbiome inside living trees

The paper explores the microbiome within living trees, revealing distinct microbial communities in heartwood and sapwood, and highlights their ecological significance.

Thetis cells induce food-specific Treg cell differentiation and oral tolerance

This study identifies Thetis cells IV as essential for food-specific Treg cell differentiation and oral tolerance, highlighting their distinct role from dendritic cells in immune regulation.

The Hyaluronan Synthase isoforms direct distinct patterns of fibroblast activation linked to fibrosis progression versus resolution following renal ischaemia

This study compares HA and HAS enzyme expression in kidney development, health, disease, and recovery, identifying distinct roles of HAS1 and HAS2 in fibroblast activation linked to fibrosis progression versus resolution.

Expansion of pneumococcal serotype 23F and 14 lineages with genotypic changes in capsule polysaccharide locus and virulence gene profiles post introduction of pneumococcal conjugate vaccine in Blantyre, Malawi

The paper analyzes whole-genome sequences of pneumococcal isolates in Malawi to show expansion of vaccine serotype lineages with genetic changes in capsule and virulence genes post-PCV13 introduction.

A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs

This paper introduces a platform for high-throughput extraction of membrane proteins into native nanodiscs while preserving their local membrane context and provides a database for optimized extraction conditions.

Exogenous mitochondrial transfer increases energy expenditure and attenuates adiposity gains in mice with diet-induced obesity

This study shows that transferring mitochondria from lean mice to obese mice increases energy expenditure, reduces adiposity, and improves metabolic health.

Utilizing gene co-expression networks with the rat kidney TXG-MAPr tool to enhance safety assessment, biomarker identification and human translation

This study builds gene co-expression networks from rat kidney toxicogenomics data and integrates them into a web tool to improve safety assessment and biomarker identification for drug development.

Reconciling the spectrum of RORγt+ antigen-presenting cells

The paper reanalyzes single-cell RNA-seq data from three studies to reconcile discrepancies in identifying RORγt+ antigen-presenting cells and their role in pTreg induction.

Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation

This study shows that heterozygous Kmt2d loss promotes medulloblastoma by enhancing tumor-promoting programs and that combining LSD1 inhibition with oxidative phosphorylation blockade reduces tumorigenicity.

Model discovery approach enables non-invasive measurement of intra-tumoral fluid transport in dynamic MRI

A physics-informed computational method measures fluid dynamics in tumors, showing differences in fluid velocity between breast and brain cancer tissues.

Meta-analysis of macrophage nanoparticle targeting across blood and solid tumors using an eLDA Topic modeling Machine Learning approach

This study uses topic modeling to analyze nanoparticle targeting of macrophages in tumors over 20 years, identifying 6 topics and trends in nanoparticle usage and therapeutic strategies.

Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer

This paper develops a platform for analyzing integral membrane proteins and lipids in intact membranes using native mass spectrometry, showing how lipid binding and membrane composition affect protein function.

Determination of oligomeric organization of membrane proteins from native membranes at nanoscale-spatial and single-molecule resolution

This paper introduces a single-molecule imaging technique to measure membrane protein oligomerization in native membranes at high spatial resolution.

Different Coexisting Mpox Lineages Were Continuously Circulating in Humans Prior to 2022

The paper identifies multiple coexisting Mpox lineages circulating in humans in Nigeria prior to the 2022 global outbreak, showing sustained human-to-human transmission and genetic changes.

Investigating manta ray collective movements via drone surveys

The paper uses drone surveys to study manta ray collective movements, identifying unique spatial and leadership patterns and suggesting individual-level interaction rules.

Allele-specific gene regulation, phenotypes, and therapeutic vulnerabilities in estrogen receptor alpha mutant endometrial cancer

This study investigates ER mutations in endometrial cancer, showing they alter gene expression and promote cancer phenotypes, and identifies potential therapeutic targets.

Consistent predictors of microbial community composition across scales in grasslands reveal low context-dependency

The paper identifies consistent predictors of microbial community composition across grassland scales, finding low context-dependency and predictable variation linked to productivity.

Global port survey quantifies commercial shippings effect on biodiversity

The paper quantifies how commercial shipping affects biodiversity by analyzing environmental DNA in ports across multiple regions, finding increased community similarity with more ship voyages and identifying non-indigenous species.

The Lyme Disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector

This study identifies a tick metabolic pathway involving ISARL that Borrelia burgdorferi exploits to establish infection, suggesting a mechanism for manipulating host metabolism.

Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastoma

This study identifies immune evasion mechanisms in checkpoint blockade-refractory glioblastoma using deep immune profiling and shows that enhancing antigen presentation can improve immunotherapy response.

Splice-switching of the insulin receptor in rhabdomyosarcoma: Rescuing the IR-B isoform for better treatment options.

This study shows that RMS tumors express more IR-A than IR-B, and reducing IR-A with SSOs decreases tumor growth by restoring IR-B expression.

Transcriptomic analysis of naïve human embryonic stem cells cultured in three-dimensional PEG scaffolds

This study shows that 3-D PEG scaffolds maintain the naive state of human ESCs and alter gene expression compared to 2-D culture.

Evaluation of pneumococcal serotyping in nasopharyngeal carriage isolates by latex agglutination, whole genome sequencing (PneumoCaT) and DNA microarray in a high pneumococcal carriage prevalence population in Malawi

The paper evaluates three pneumococcal serotyping methods in Malawi, finding high concordance between latex agglutination, whole genome sequencing, and DNA microarray, with microarray improving detection of low-abundance vaccine serotypes.

Quantitative analysis of the splice variants expressed by the major hepatitis B virus genotypes

The paper identifies 6 novel and 6 previously known HBV splice variants across 4 genotypes using RNA-seq, revealing genotype-specific expression patterns and suggesting functional importance.

Phenotypic variation in two widespread Caribbean corals, Porites astreoides and P. divaricata, between mangrove and lagoon habitats

This study compares phenotypic differences in two Caribbean coral species between mangrove and lagoon habitats, finding consistent intraspecific variation that suggests adaptation or plasticity to environmental conditions.

Improving Landsat predictions of rangeland fractional cover with multitask learning and uncertainty

The paper improves rangeland fractional cover predictions using multitask learning and provides pixel-level uncertainty estimates, enhancing management tools with better accuracy and confidence measures.

Nature based measures increase freshwater biodiversity in agricultural catchments

This study shows that adding clean-water ponds in agricultural catchments increases freshwater plant biodiversity, while ecosystem services measures only partially offset species loss.

Chlorotoxin Redirects Chimeric Antigen Receptor T Cells for Specific and Effective Targeting of Glioblastoma

This study develops a CAR T cell therapy using chlorotoxin to target glioblastoma with high specificity and potency, overcoming tumor heterogeneity challenges.