ImmunologybioRxivPreprint
PD-L1 blockade restores CAR T cell activity through IFNγ-regulation of CD163+ macrophages
Y. Yamaguchi, J. Gibson, K. Ou…·S. J. Priceman
This study shows that PD-L1 blockade enhances CAR T cell activity by altering macrophage phenotypes through IFNγ signaling in the tumor microenvironment.
DOI 10.1101/2022.01.25.477150