C. Martinez

Optogenetic control of a horizontally acquired region in yeast prevent stuck fermentations

This study uses optogenetics to show that region A genes in wine yeast are essential for completing fermentation under low nitrogen conditions.

Synthesis and pharmacological characterization of UVI3502, a novel cannabinoid receptor 1 (CB1) antagonist/inverse agonist

This paper synthesizes and characterizes UVI3502, a novel CB1 receptor antagonist/inverse agonist, showing high affinity for CB1 and low affinity for CB2, with potential interactions with GPR55.

Chromosome-scale pearl millet genomes reveal a CARLACTONOIC ACID METHYL TRANSFERASE as key determinant of strigolactone pattern and Striga susceptibility

The paper identifies a CLAMT1 gene responsible for strigolactone production and Striga susceptibility in pearl millet by comparing genome assemblies of susceptible and resistant lines.

Ontogeny of the organized nasopharynx-associated lymphoid tissue in rainbow trout

This study identifies the developmental sequence of organized nasopharynx-associated lymphoid tissue (O-NALT) in rainbow trout, showing CD8+ T cells initiate its formation and that O-NALT is fully formed by 1400DD, marking a potential earliest time for effective mucosal vaccination.

The immune response to a fungus in pancreatic cancer samples

The paper examines the immune response in pancreatic cancer samples and identifies up-regulated immune-related genes and complement cascade activation associated with tumor progression.

LIFR recruits HGF-producing neutrophils to promote liver injury repair and regeneration

This study shows that LIFR in hepatocytes regulates neutrophil recruitment and activity to promote liver regeneration through CXCL1-CXCR2 and cholesterol-HGF pathways.

Dissemination of IncI plasmid encoding blaCTX-M-1 is not hampered by its fitness cost in the pig's gut.

The study shows that an IncI plasmid encoding blaCTX-M-1 does not significantly reduce bacterial fitness in the pig gut, allowing its dissemination despite a minor growth rate difference.

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

This study develops TAG72-CAR T cells with antigen-dependent IL-12 signaling to enhance anti-tumor activity and systemic disease targeting in ovarian cancer.

A Bayesian network approach to assess the influence of climate change and pesticide use practices on the ecological risks of pesticides in a protected Mediterranean wetland

This study uses a Bayesian network to assess how climate change and pesticide use practices affect ecological risks in a Mediterranean wetland, finding that future climate conditions and reduced pesticide use can lower risks.

PD-L1 blockade restores CAR T cell activity through IFNγ-regulation of CD163+ macrophages

This study shows that PD-L1 blockade enhances CAR T cell activity by altering macrophage phenotypes through IFNγ signaling in the tumor microenvironment.

Pre-conditioning Modifies the Tumor Microenvironment to Enhance Solid Tumor CAR T Cell Efficacy and Endogenous Immunity

This study shows that cyclophosphamide pre-conditioning improves CAR T cell efficacy against solid tumors by modifying the immunosuppressive tumor microenvironment without harming normal tissues.

Precise transcriptional control of cellular quiescence by BRAVO/WOX5 complex in Arabidopsis roots

The paper identifies the regulatory interaction between BRAVO and WOX5 in Arabidopsis root quiescent center cells, showing their mutual regulation and role in maintaining root growth and architecture.

Building a local community of practice in scientific programming for Life Scientists

This paper describes how to build local communities of practice for life scientists to improve scientific programming skills and data analysis practices.

Morphological plant modeling: Unleashing geometric and topological potential within the plant sciences

This paper discusses the importance of mathematical modeling in plant morphology and outlines challenges and opportunities for integrating geometric and topological approaches in plant science research and education.