Tuning antiviral CD8 T-cell response via proline-altered peptide ligand vaccination
A. Achour, A. D. Duru, R. Sun, E. B. Allerbring, J. Chadderton, N. Kadri, X. Han, H. Uchtenhagen, C. Madhurantakam, S. Pellegrino, T. Sandalova, P.-A. Nygren, S. J. Turner
This paper shows that modifying peptides with proline can restore CD8 T-cell recognition of viral escape variants, enhancing vaccine effectiveness against immune evasion.
bioRxiv · Dec 2, 2019Immunology