S. J. Turner

This study shows that transcription factors maintain CD8+ T cell naivety by enforcing a distinct chromatin architecture that remodels upon activation.

The paper investigates how IFN-gamma-secreting CD4+ T-cells alter the transcriptional output of IL-6 by redirecting STAT1 and STAT3 to Alu-like retroelements during inflammation.

The paper uses mathematical models and focus reduction assays to show that influenza virus neutralization and antibody consumption can lead to bistable growth kinetics, explaining reinfection and vaccine efficacy.

This study identifies KDM6B-dependent chromatin remodelling as critical for virus-specific CD8+ T cell differentiation and memory formation.

This paper shows that modifying peptides with proline can restore CD8 T-cell recognition of viral escape variants, enhancing vaccine effectiveness against immune evasion.

This paper develops a conditional KDM6b shRNA mouse model and shows that its knockdown reduces CD8+ T cell responses to influenza A infection without affecting T-BET expression.