R. Sun

The up-regulation of TGF-beta1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages

This study shows that miRNA-132-3p/WT1/TGF-beta1 axis regulates the differentiation of THP-1 leukemia cells into macrophages.

Structures of Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus virions reveal species-specific tegument and envelope features

This study uses cryoET and deep learning to reveal structural differences in the tegument and envelope of EBV and KSHV virions compared to other herpesviruses.

Temporal-spatially metabolic reprogramming rewires the H3K27ac landscape to enable the initiation of liver regeneration

This study identifies metabolic reprogramming and its impact on the H3K27ac epigenetic landscape during liver regeneration.

Mitochondrial Protein Carboxyl-Terminal Alanine-Threonine Tailing Promotes Human Glioblastoma Growth by Regulating Mitochondrial Function

This study identifies msiCAT-tailing of mitochondrial proteins as a mechanism promoting glioblastoma growth by enhancing mitochondrial function and reducing apoptosis.

Assessing drug uptake and response differences in 2D and 3D cellular environments using stimulated Raman scattering microscopy

This study compares drug uptake and response in 2D and 3D cell cultures using SRS microscopy, finding that 3D spheroids show greater drug tolerance despite similar intracellular drug levels.

HNF&alpha is a target of the Wnt/beta-catenin pathway and regulates colorectal carcinogenesis

This study shows HNF4 is upregulated in colorectal cancer and promotes tumorigenesis by being activated by the Wnt/β-catenin pathway.

Global RNA Virome in Wastewater Treatment Plants Reveals Ecological Insights and Human Health Implications

This study analyzes RNA virus diversity in wastewater treatment plants, identifying new viral lineages and their ecological and health implications.

Postmortem MRI of Tissue Frozen at Autopsy

This paper describes a method to image frozen postmortem human tissue using MRI at sub-zero temperatures while maintaining tissue integrity and biosafety.

Transcription of a centromere-enriched retroelement and local retention of its RNA are significant features of the CENP-A chromatin landscape

This study investigates Jockey-3 retroelement transcription and RNA localization at centromeres in Drosophila, showing its correlation with CENP-A and potential role in centromere maintenance.

Conversion of monoclonal IgG to dimeric and secretory IgA restores neutralizing ability and prevents infection of Omicron lineages

Engineered dimeric and secretory IgA1 neutralized Omicron variants with higher potency than parental IgG.

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

Evolutionarily Conserved CKI1-Mediated Two-Component Signaling is Required for Female Germline Specification in Marchantia polymorpha

This study identifies MpCKI1 as a conserved two-component signaling component required for female germline specification in Marchantia polymorpha.

Biosynthesis of gibberellin-related compounds modulates far-red light responses in the liverwort Marchantia polymorpha

This study shows that GA-related compounds in liverworts modulate far-red light responses, revealing evolutionary conservation and functional divergence in GA biosynthesis.

Targeting Sex Determination to Suppress Mosquito Populations

This paper develops a CRISPR-based sterile insect technique to suppress Aedes aegypti populations by generating sterile males that outcompete wild mosquitoes.

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling

This study identifies CD25 as a scaffold for phosphatases that regulate B-cell signaling and oncogenic processes, with opposing effects on B-cell malignancies and autoimmunity.

Multimodal meta-analysis of fecal metagenomes reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer

This study identifies microbial single nucleotide variants (SNVs) as superior biomarkers for early detection of colorectal cancer, outperforming species-level signatures in multiple validation cohorts.

Oncogene-like addiction to aneuploidy in human cancers

This study demonstrates that trisomy of chromosome 1q is essential for malignant growth in cancers and shows that TP53 mutations are mutually exclusive with 1q aneuploidy.

ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation

This paper introduces ROTACs, signaling-incompetent R-spondin chimeras that target transmembrane proteins for degradation, demonstrating efficacy against PD-L1 in melanoma cells.

Personalized Deep Learning based Source Imaging Framework Improves the Imaging of Epileptic Sources from MEG Interictal Spikes

This paper introduces a personalized deep learning framework for imaging epileptic sources from MEG interictal spikes, showing improved accuracy and robustness in localization.

Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-specific Transcriptome and Molecular Subtype

This study uses deep learning on plasma extracellular vesicle RNA to predict cancer subtypes, monitor treatment effects, and identify gene fusions and neoepitopes without tissue sampling.

SARS-CoV-2 variants show temperature-dependent enhanced polymerase activity in the upper respiratory tract and high transmissibility

This study shows SARS-CoV-2 variants with P323L or P323L/G671S mutations in NSP12 have enhanced polymerase activity at 33°C and higher transmissibility in ferrets.

Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin-beta receptor signaling

The paper shows that leukemic cells activate LTβR signaling in mesenchymal stem cells, suppressing IL7 production and lymphopoiesis while promoting leukemia growth.

Tumor suppressor p53 deficiency increases tumor immunogenicity through promoting IL33-mediated anti-tumor immune responses

This study shows that p53 deficiency in tumors enhances immunogenicity by increasing IL-33, which improves response to PD-1 ICB therapy in a mouse model.

Cellular Uptake of His-Rich Peptide Coacervates Occurs by a Macropinocytosis-Like Mechanism

This study investigates how His-rich peptide coacervates enter cells, finding they use a macropinocytosis-like mechanism involving cytoskeleton rearrangement and filopodia capture.

NSUN2-mediated mRNA m5C Modification Regulates the Progression of Hepatocellular Carcinoma

This study identifies NSUN2-mediated m5C modification as a regulator of hepatocellular carcinoma progression through oncogene expression and Ras signaling pathway modulation.

FoxP3-mediated blockage of ryanodine receptor 2 is the molecular basis for the contact-based suppression by regulatory T cells

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

Computation of Antigenicity Predicts SARS-CoV-2 Vaccine Breakthrough Variants

This paper develops a computational model to predict SARS-CoV-2 variant antigenicity from sequence data, showing high accuracy in predicting neutralisation titre decreases for known variants and Omicron.

Scrutiny of human lung infection by SARS-CoV-2 and associated human immune responses in humanized mice

This study shows that humanized mice can be infected by SARS-CoV-2, leading to immune responses and immunopathology, providing a model for studying the virus and testing therapies.

Coordination between growth and stress responses by DELLA in the liverwort Marchantia polymorpha

This study shows that DELLA in the liverwort Marchantia polymorpha coordinates growth and stress responses, similar to vascular plants, and interacts with MpPIF to promote oxidative stress tolerance.

Gene mutations in members of the PI3K/Akt signalling pathway are related to immune thrombocytopenia pathogenesis

This study identifies gene mutations in the PI3K/Akt pathway associated with immune thrombocytopenia (ITP) using whole-exome sequencing and functional analysis.