Phenotypic Characterization of Liver Sinusoidal Endothelial Cells on the Human Liver-Chip for Potential in vitro Therapeutic Antibody Pharmacology Applications
P. L. Candarlioglu, S. Jadalannagari, J. Chaff, J. Velez, S. R. Joshipura, M. Kanellias, A. P. Simpson, S. J. Kerns, L. Ewart, M. Hegde, J. Ekert
This paper describes a Liver-Chip model that maintains CD32B expression on LSECs for 14 days, enabling in vitro studies of therapeutic antibody pharmacology.
bioRxiv · Mar 4, 2022 · PreprintBioengineering