Author

M. Hegde

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1

Frequent Co-Authors

J. G. Doench· 2 shared A. L. Chaves Valadao· 1 shared A. P. Simpson· 1 shared A. Rebendenne· 1 shared A. V. McGee· 1 shared B. Bonaventure· 1 shared C. Goujon· 1 shared D. Giovannini· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBioengineering

J. G. Doench

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Author profile →

3 papers

Recent·Most cited

Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening

P. C. DeWeirdt, A. V. McGee, F. Zheng, I. Nwolah, M. Hegde, J. G. Doench

This study improves sgRNA activity predictions by incorporating tracrRNA sequence variations, showing better performance than existing models on a new dataset.

bioRxiv · Jun 27, 2022Bioengineering

Phenotypic Characterization of Liver Sinusoidal Endothelial Cells on the Human Liver-Chip for Potential in vitro Therapeutic Antibody Pharmacology Applications

P. L. Candarlioglu, S. Jadalannagari, J. Chaff, J. Velez, S. R. Joshipura, M. Kanellias, A. P. Simpson, S. J. Kerns, L. Ewart, M. Hegde, J. Ekert

This paper describes a Liver-Chip model that maintains CD32B expression on LSECs for 14 days, enabling in vitro studies of therapeutic antibody pharmacology.

bioRxiv · Mar 4, 2022 · PreprintBioengineering

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal coronaviruses

A. Rebendenne, P. Roy, B. Bonaventure, A. L. Chaves Valadao, L. Desmarets, Y. Rouille, M. Tauziet, M. Arnaud-Arnould, D. Giovannini, Y. Lee, P. DeWeirdt, M. Hegde, F. Garcia de Gracia, J. McKellar, M. Wencker, , C. Goujon

The paper performs bidirectional CRISPR screens to identify host factors regulating SARS-CoV-2, MERS-CoV, and seasonal coronaviruses, revealing new anti-viral proteins and general coronavirus cofactors.

bioRxiv · May 19, 2021Microbiology