Author

J. Velez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Ecology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Assay:flow cytometry· 1

Frequent Co-Authors

L. Ewart· 2 shared M. Kanellias· 2 shared S. Jadalannagari· 2 shared S. R. Joshipura· 2 shared A. Apostolou· 1 shared A. C. Rizos· 1 shared A. P. Simpson· 1 shared A. R. Heng· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersBioengineering

L. Ewart

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Discovery of the First-in-class G9a/GLP PROTAC Degrader

J. Velez, Y. Han, H. Yim, P. Yang, Z. Deng, K. Park, M. Kabir, H. Kaniskan, Y. Xiong, J. Jin

This paper discovers a first-in-class PROTAC degrader for G9a/GLP, showing effective degradation and superior anticancer activity compared to existing inhibitors.

bioRxiv · Feb 26, 2024Biochemistry

Phenotypic Characterization of Liver Sinusoidal Endothelial Cells on the Human Liver-Chip for Potential in vitro Therapeutic Antibody Pharmacology Applications

P. L. Candarlioglu, S. Jadalannagari, J. Chaff, J. Velez, S. R. Joshipura, M. Kanellias, A. P. Simpson, S. J. Kerns, L. Ewart, M. Hegde, J. Ekert

This paper describes a Liver-Chip model that maintains CD32B expression on LSECs for 14 days, enabling in vitro studies of therapeutic antibody pharmacology.

bioRxiv · Mar 4, 2022 · PreprintBioengineering

Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implications

L. Ewart, A. Apostolou, S. A. Briggs, C. V. Carman, J. T. Chaff, A. R. Heng, S. Jadalannagari, J. Janardhanan, K.-J. Jang, S. R. Joshipura, M. Kadam, M. Kanellias, V. J. Kujala, G. Kulkarni, C. Y. Le, , D. Levner

The paper evaluates a Liver-Chip's ability to predict drug-induced liver injury and estimates its economic impact in pharmaceutical R&D.

bioRxiv · Dec 14, 2021 · PreprintPharmacology & Toxicology

Phylogenetic diversity of 200+ isolates of the ectomycorrhizal fungus Cenococcum geophilum associated with Populus trichocarpa soils in the Pacific Northwest, USA and comparison to globally distributed representatives

J. Velez, R. Morris, R. Vilgalys, J. Labbe, C. W. Schadt

The paper analyzes phylogenetic diversity of Cenococcum geophilum isolates from Populus trichocarpa soils in the Pacific Northwest and globally distributed isolates, revealing cryptic species and recombination patterns.

bioRxiv · Mar 24, 2020Ecology