MicrobiologybioRxiv
The actin nucleator Spir-1 is a virus restriction factor that promotes IRF3 activation
A. A. Torres, S. L. Macilwee, A. Rashid…·G. L. Smith
This paper identifies Spir-1 as a virus restriction factor that enhances IRF3 activation in response to RNA viruses and is targeted by the viral protein K7 to suppress antiviral responses.