Author

J. D. Hinkle

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. E. P. Syka· 2 shared A. ElSohly· 1 shared C. Mullen· 1 shared C. Tsai· 1 shared D. DiCara· 1 shared G. C. McAlister· 1 shared J. Coon· 1 shared J. Gober· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

J. E. P. Syka

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Author profile →

2 papers

Recent·Most cited

Boosting the Sensitivity of Quantitative Single-Cell Proteomics with Activated Ion-Tandem Mass Tags (AI-TMT)

T. Peters-Clarke, Y. Liang, K. L. Mertz, K. W. Lee, M. S. Westphall, J. D. Hinkle, G. C. McAlister, J. E. P. Syka, R. T. Kelly, J. Coon

This paper introduces AI-TMT, a method enhancing single-cell proteomics sensitivity by improving reporter ion generation, resulting in higher signal and faster analysis.

bioRxiv · Feb 24, 2024 · PreprintBiochemistry

Exposing the molecular heterogeneity of glycosylated biotherapeutics

L. F. Schachner, C. Mullen, W. Phung, J. D. Hinkle, M. I. Beardsley, T. Bentley, P. Day, C. Tsai, S. Sukumaran, T. Baginski, D. DiCara, N. Agard, M. Masureel, J. Gober, A. ElSohly, , W. Sandoval

This paper introduces a new method for analyzing glycoform heterogeneity in biotherapeutics using mass spectrometry and bioinformatics, showing its effectiveness in measuring proteoform diversity and correlating glycoform sub-populations with pharmacological properties.

bioRxiv · May 10, 2023Biochemistry