J. Coon

Boosting the Sensitivity of Quantitative Single-Cell Proteomics with Activated Ion-Tandem Mass Tags (AI-TMT)

This paper introduces AI-TMT, a method enhancing single-cell proteomics sensitivity by improving reporter ion generation, resulting in higher signal and faster analysis.

Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

Cryogenic Soft Landing Improves Structural Preservation of Protein Complexes

This paper introduces a cryogenic landing system that improves structural preservation of protein complexes for cryo-electron microscopy.

Nuclear cytoglobin associates with HMGB2 and regulates DNA damage and genome-wide transcriptional output in the vasculature

This study identifies nuclear cytoglobin's role in regulating DNA damage and transcriptional output in vascular smooth muscle cells through its interaction with HMGB2.

Early Endosome Capture Proteomics and its Application to Amyloid Precursor Protein Intramembrane Processing by β and γ-Secretases

This paper develops a method to isolate early endosomes and uses it to study amyloid precursor protein processing by β and γ-secretases in these compartments.

Nano-Emulsion Adjuvant Enhances Cross-presentation by Lipid Body Formation Independent of Glycolysis

This study shows that the nano-emulsion adjuvant Adjuplex enhances cross-presentation in dendritic cells without requiring glycolysis, relying instead on lipid body formation and ROS.

Multi-omic mitoprotease profiling defines a role for Oct1p in coenzyme Q production

The paper identifies Oct1p as a mitoprotease that processes Coq5p to enhance coenzyme Q production in yeast.

Conserved lipid and small molecule modulation of COQ8 reveals regulation of the ancient UbiB family

This study identifies lipid and small molecule modulators of COQ8, an ancient UbiB family protein, and establishes a chemical genetic system to study its role in CoQ biosynthesis.