TCR transgenic clone selection guided by immune receptor analysis and single cell RNA expression of polyclonal responders
N. Debeuf, S. Lameire, M. Vanheerswynghels, J. Deckers, C. De Wolf, W. Toussaint, R. Verbeke, K. Verstaen, H. Hammad, S. Vanhee, B. N. Lambrecht
The paper develops a method to select optimal TCR transgenic clones using single-cell RNA sequencing and TCR repertoire analysis, enabling the generation of CORSET8 mice specific to SARS-CoV-2 Spike protein.
bioRxiv · Mar 27, 2024Immunology