Author

S. De Cae

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein sequence· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

B. Schepens· 2 shared C. Lonigro· 2 shared D. Fijalkowska· 2 shared H. Demol· 2 shared J. C. Zavala Marchan· 2 shared J. Neyts· 2 shared K. Roose· 2 shared K. Sedeyn· 2 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

B. Schepens

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Author profile →

2 papers

Recent·Most cited

Yeast-based production platform for potent and stable heavy chain-only antibodies

C. Lonigro, H. Eeckhaut, R. A. Symakani, K. Roose, B. Schepens, K. Sedeyn, A.-S. De Smet, J. C. Zavala Marchan, P. Vanhaverbeke, S. Vanmarcke, K. Claes, S. De Cae, H. Demol, S. Devos, D. Fijalkowska, , N. Callewaert

This paper presents a yeast-based platform for producing stable and potent heavy chain-only antibodies, demonstrating its effectiveness with an anti-SARS-CoV-2 example.

bioRxiv · Mar 4, 2024 · PreprintMicrobiology

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that bind a conserved membrane proximal epitope of the spike

S. De Cae, I. Van Molle, L. van Schie, S. R. Shoemaker, J. Deckers, N. Debeuf, S. Lameire, W. Nerinckx, K. Roose, D. Fijalkowska, S. Devos, A.-S. Desmet, J. C. Zavala Marchan, T. Venneman, G. H. Ghassabeh, , B. Schepens

The paper identifies ultrapotent SARS-CoV-2-neutralizing nanobodies that bind a conserved epitope on the spike protein, showing therapeutic efficacy in hamsters.

bioRxiv · Mar 10, 2023 · PreprintMicrobiology