Author

K. Roose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

B. Schepens· 4 shared X. Saelens· 4 shared L. van Schie· 3 shared N. Callewaert· 3 shared C. Lonigro· 2 shared D. De Vlieger· 2 shared D. Fijalkowska· 2 shared D. Jochmans· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMicrobiology

B. Schepens

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Author profile →

4 papers

Recent·Most cited

Yeast-based production platform for potent and stable heavy chain-only antibodies

C. Lonigro, H. Eeckhaut, R. A. Symakani, K. Roose, B. Schepens, K. Sedeyn, A.-S. De Smet, J. C. Zavala Marchan, P. Vanhaverbeke, S. Vanmarcke, K. Claes, S. De Cae, H. Demol, S. Devos, D. Fijalkowska, , N. Callewaert

This paper presents a yeast-based platform for producing stable and potent heavy chain-only antibodies, demonstrating its effectiveness with an anti-SARS-CoV-2 example.

bioRxiv · Mar 4, 2024 · PreprintMicrobiology

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that bind a conserved membrane proximal epitope of the spike

S. De Cae, I. Van Molle, L. van Schie, S. R. Shoemaker, J. Deckers, N. Debeuf, S. Lameire, W. Nerinckx, K. Roose, D. Fijalkowska, S. Devos, A.-S. Desmet, J. C. Zavala Marchan, T. Venneman, G. H. Ghassabeh, , B. Schepens

The paper identifies ultrapotent SARS-CoV-2-neutralizing nanobodies that bind a conserved epitope on the spike protein, showing therapeutic efficacy in hamsters.

bioRxiv · Mar 10, 2023 · PreprintMicrobiology

STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

R. Boudewijns, H. J. Thibaut, S. J. F. Kaptein, R. Li, V. Vergote, L. Seldeslachts, C. De Keyzer, L. Bervoets, S. Sharma, J. Van Weyenbergh, L. Liesenborghs, J. Ma, S. Jansen, D. Van Looveren, T. Vercruysse, , X. Saelens

This study shows that STAT2 signaling both restricts SARS-CoV-2 spread and causes severe pneumonia in infected hamsters.

bioRxiv · Apr 23, 2020 · PreprintMicrobiology

Structural Basis for Potent Neutralization of Betacoronaviruses by Single-domain Camelid Antibodies

D. Wrapp, D. De Vlieger, K. S. Corbett, G. M. Torres, W. Van Breedam, K. Roose, L. van Schie, VIB-CMB COVID-19 Response Team, M. Hoffmann, S. Pöhlmann, B. S. Graham, N. Callewaert, B. Schepens, X. Saelens, J. S. McLellan

This study isolates and characterizes VHH antibodies that neutralize MERS-CoV, SARS-CoV-1, and SARS-CoV-2 by blocking receptor binding, with structural insights into their epitopes and cross-reactivity.

bioRxiv · Mar 26, 2020Microbiology