Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer
E. Sanij, K. M. Hannan, S. Yan, X. Xuan, J. E. Ahern, K. T. Chan, J. Son, O. Kondrashova, E. Lieschke, M. J. Wakefield, A. S. Trigos, D. Frank, S. Ellis, C. Cullinane, J. Kang, , R. B. Pearson
This study shows CX-5461, an RNA polymerase I inhibitor, enhances PARP inhibitor efficacy in HR-deficient HGSOC by inducing replication stress and DNA damage, overcoming resistance mechanisms.
bioRxiv · Apr 29, 2019 · PreprintCancer Biology