J. Son

Cryptosporidium infection of human small intestinal epithelial cells induces type III interferon and impairs infectivity of Rotavirus.

This study develops a human air-liquid interface culture system for Cryptosporidium hominis, revealing it induces type III interferon and reduces Rotavirus infectivity.

Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea

This study identifies Cyb5r3 downregulation as a mechanism of sulfonylurea failure and shows that a Cyb5r3 activator can reverse this failure in an animal model.

Triple Notch/Tgfβ/FoxO1 blockade converts multiple intestinal sub-lineages into β-like cells and lowers glycemia in diabetic animals

Mesalamine Reduces Intestinal ACE2 Expression Without Modifying SARS-CoV-2 Infection or Disease Severity in Mice.

This study investigates whether mesalamine affects SARS-CoV-2 infection and disease severity in mice and human intestinal cells, finding no change in viral levels but reduced ACE2 expression.

Phospho-dependent Signaling during the General Stress Response by the Atypical Response Regulator and ClpXP Adaptor RssB

This study reports crystal structures of RssB's receiver domain in unphosphorylated and phosphomimic forms, revealing structural differences and suggesting a novel signaling mechanism in E. coli's stress response.

JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis

The paper identifies JIB-04 as a broad-spectrum antiviral that inhibits SARS-CoV-2 replication and coronavirus pathogenesis in vitro and in vivo.

Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion

The paper identifies CH25H and its product 25HC as inhibitors of SARS-CoV-2 replication by blocking membrane fusion.

Sensitivity of radio-photoluminescence glass dosimeters to accumulated doses

This study examines how accumulated doses affect radio-photoluminescence glass dosimeters (RPLGDs) under different photon energies and irradiation conditions.

AFF3 and BACH2 are master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetes

The paper identifies AFF3 and BACH2 as master regulators of metabolic inflexibility, β/α-cell transition, and dedifferentiation in type 2 diabetes using single-cell analysis of human islets.

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

This study shows CX-5461, an RNA polymerase I inhibitor, enhances PARP inhibitor efficacy in HR-deficient HGSOC by inducing replication stress and DNA damage, overcoming resistance mechanisms.