D. Frank

The bat Influenza A virus subtype H18N11 induces nanoscale MHCII clustering upon host cell attachment

This study shows that bat influenza A virus H18N11 attaches to MHCII clusters on host cells, causing local clustering of MHCII molecules similar to immunological synapse formation.

Automated adjustment of metabolic niches enables the control of natural and engineered microbial co-cultures

This paper introduces AAMN, an automated method to control microbial co-cultures by adjusting metabolic niches, showing its effectiveness in stabilizing both cooperative and competitive cultures.

Microbiota-dependent indole production is required for the development of collagen-induced arthritis

This study shows that microbiota-dependent indole production is essential for collagen-induced arthritis development and identifies potential therapeutic targets.

Genomic and metabolic instability during long-term fermentation of an industrial Saccharomyces cerevisiae strain engineered for C5 sugar utilization.

Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

This study identifies Trabid mutations that disrupt APC trafficking and neurite growth by impairing DUB activity or STRIPAK binding, leading to neurodevelopmental defects.

Fitness cost associated with cell phenotypic switching drives population diversification dynamics and controllability

The paper studies how fitness costs from phenotypic switching affect population diversification and controllability in bacteria and yeast, identifying three diversification regimes and demonstrating control via a Segregostat interface.

Amino acid auxotrophies in human gut bacteria are linked to higher microbiome diversity and long-term stability

This study links amino acid auxotrophies in human gut bacteria to increased microbiome diversity and long-term stability through a combined metabolomic, metagenomic, and metabolic modeling approach.

Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction

The paper identifies a small molecule that inhibits the Tax-1-hDLG1 interaction, reducing HTLV-1 cell-to-cell transmission in a T-cell model.

Aging-associated augmentation of gut microbiome virulence capability drives sepsis severity.

This study shows that aging increases gut microbial virulence, contributing to more severe sepsis in older adults.

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

The paper shows that a common MLKL polymorphism, S132P, enhances necroptotic activity in human cells and impairs recovery from infection in mice.

Biochemical characterization of a human septin octamer

This study characterizes the biochemical properties of a human septin octamer, showing its polymerization behavior and unique GTP hydrolysis dynamics.

Multi-omic analysis along the gut-brain axis points to a functional architecture of autism

The paper identifies a functional architecture of autism along the gut-brain axis using multi-omic data, revealing microbial and metabolic profiles linked to autism symptoms.

Multi-omics approach reveals new insights into the gut microbiome of Galleria mellonella (Lepidoptera:Pyralidae) exposed to polyethylene diet

This study uses a multi-omics approach to analyze the gut microbiome of Galleria mellonella fed a polyethylene diet, identifying key bacterial families and potential plastic-degrading enzymes.

The inflammasome-activated cytokine IL-1 is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential

This study shows that IL-1β is ubiquitylated and degraded to limit its inflammatory activity, with specific ubiquitin modifications and electrostatic interactions playing key roles.

Dissecting CD8+ T cell pathology of severe SARS-CoV-2 infection by single-cell epitope mapping

This study identifies an immunogenic CD8+ T cell epitope associated with severe SARS-CoV-2 infection and characterizes its pathological features.

Reducing phenotypic instabilities of microbial population during continuous cultivation based on cell switching dynamics

This paper demonstrates that allowing microbial cells to switch phenotypes around a threshold, rather than enforcing a fixed trajectory, leads to more stable population behavior during continuous cultivation.

A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AML

This study identifies JAK1 as a therapeutic target in AF10-rearranged AML by showing its role in JAK/STAT-mediated inflammatory signaling and oncogenesis.

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

This study shows CX-5461, an RNA polymerase I inhibitor, enhances PARP inhibitor efficacy in HR-deficient HGSOC by inducing replication stress and DNA damage, overcoming resistance mechanisms.