S. Yan

MAP4 kinase-regulated reduced CLSTN1 expression in medulloblastoma is associated with increased invasiveness

This study shows that reduced CLSTN1 expression, regulated by MAP4 kinase, increases invasiveness in medulloblastoma by affecting cell-cell interactions and growth factor responses.

Editing of endogenous tubulins reveals varying effects of tubulin posttranslational modifications on axonal growth and regeneration

This study edits endogenous tubulin to assess how different posttranslational modifications affect axonal growth and regeneration in C. elegans neurons.

Visualizing PIEZO1 Localization and Activity in hiPSC-Derived Single Cells and Organoids with HaloTag Technology

This study uses HaloTag technology to visualize PIEZO1 localization and activity in hiPSC-derived cells and organoids, enabling mechanotransduction studies with high temporal resolution.

UDP-glucosyltransferase 71C4 regulates seed development by redistributing phenylpropanoid metabolism in cotton

This study identifies UGT71C4's role in regulating seed development and yield traits in cotton by modulating phenylpropanoid metabolism, lignin, and flavonoid pathways.

Inflammation causes insulin resistance via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels

This study identifies the IRF3/AIG1 axis in adipocytes as a mechanism linking obesity-induced inflammation to insulin resistance and suggests AIG1 inhibition as a therapeutic approach.

A compact breast shape acquisition system for improving diffuse optical tomography image reconstructions

This paper develops a compact breast shape acquisition system that improves diffuse optical tomography image reconstructions by reducing surface estimation errors and increasing absorption coefficient accuracy.

Systematic mutagenesis reveals critical effector functions in the assembly and dueling of the H1-T6SS in Pseudomonas aeruginosa

This study systematically mutagenizes H1-T6SS effectors and VgrG proteins in Pseudomonas aeruginosa to reveal their roles in T6SS assembly and dueling responses.

Actin-driven protrusions generate rapid long-range membrane tension propagation in cells

The paper uses optogenetics and optical tweezers to show that actin-driven protrusions enable rapid, long-range membrane tension propagation, contrasting with localized force application.

A dueling-competent signal-sensing module guides precise delivery of cargo proteins into target cells by engineered Pseudomonas aeruginosa

This paper introduces a protein delivery platform called DUEC that selectively delivers cargo into target cells using engineered bacterial systems.

PLK1 O-GlcNAcylation is essential for dividing mammalian cells and inhibits uterine carcinoma

This study identifies PLK1 O-GlcNAcylation as critical for cell division and shows its role in suppressing uterine carcinoma through biochemical and mouse model experiments.

The multi-BRCT domain protein DDRM2 is required for homologous recombination in plants

A genetic screen in Arabidopsis identifies DDRM2, a multi-BRCT domain protein required for homologous recombination and regulated by SOG1.

The tRNA thiolation-mediated translational control is essential for plant immunity

This study identifies tRNA thiolation as essential for plant immunity by showing its role in regulating NPR1 translation and salicylic acid signaling in Arabidopsis.

A transcytotic actin shift polarizes vesicle trajectories and partitions apicobasal epithelial membrane domains

The paper shows that actin dynamics determine apical membrane domain positioning in C. elegans intestine, independent of PAR proteins, by directing vesicle trajectories toward the future apical domain.

Graphics processing unit-accelerated Monte Carlo simulation of polarized light in complex three-dimensional media

The paper develops a GPU-accelerated Monte Carlo method for simulating polarized light in 3D heterogeneous tissues, achieving a 931-fold speedup over CPU-based simulations.

MCX Cloud - a modern, scalable, high-performance and in-browser Monte Carlo simulation platform with cloud computing

MCX Cloud provides an open-source, web-based Monte Carlo simulation platform with cloud computing capabilities for biophotonics researchers.

Obesity influences composition of salivary and fecal microbiota and impacts the interactions between bacterial taxa

This study examines how obesity affects salivary and fecal microbiota composition and interactions, finding distinct microbial dynamics in saliva linked to obesity status.

Dry heat sterilization as a method to recycle N95 respirator masks: the importance of fit

This study shows that dry heat decontaminates N95 respirators and preserves their fit, unlike autoclaving which compromises fit and makes them unusable.

To knot or not to knot: Multiple conformations of the SARS-CoV-2 frameshifting RNA element

The paper identifies multiple structural conformations of the SARS-CoV-2 frameshifting RNA element and their potential roles in viral replication and therapeutic targeting.

Breaching the cell-envelope barriers of gram-positive and fungal microbes by a type VI secretion system in Acidovorax citrulli

This study identifies a type VI secretion system in Acidovorax citrulli that can breach gram-positive and fungal cell envelopes, with RhsB as a key effector.

Profiles of Expression pattern and tissue distribution of host defense peptides genes in different chicken (Gallus gallus) breeds related to body weight

The paper examines HDP gene expression and tissue distribution in different chicken breeds, finding correlations between body weight, age, and HDP expression in immune organs and intestine.

Light transport modeling in highly complex tissues using implicit mesh-based Monte Carlo algorithm

This paper introduces an efficient implicit mesh-based Monte Carlo method for simulating light transport in complex tissues, significantly reducing memory usage and computational time.

A hybrid mesh and voxel based Monte Carlo algorithm for accurate and efficient photon transport modeling in complex bio-tissues

This paper introduces a hybrid Monte Carlo algorithm for photon transport modeling in complex bio-tissues, improving accuracy and efficiency over voxel-based methods.

Structure-Altering Mutations of the SARS-CoV-2 Frame Shifting RNA Element

This paper uses computational methods to identify key structural features of the SARS-CoV-2 FSE RNA element and proposes mutations to disrupt viral translation.

An Antioxidant Enzyme Therapeutic for COVID-19

This paper describes a catalase-based therapeutic for COVID-19 that reduces oxidative stress and cytokine production in human and animal models without toxicity.

Dual mechanism estrogen receptor inhibitors

This paper develops dual-mechanism ER inhibitors that use two distinct targeting moieties to suppress ER activity in breast cancer cells and resistance models.

Rapid detection of SARS-CoV-2 and other respiratory viruses by using LAMP method with Nanopore Flongle workflow

This paper describes a rapid method using LAMP and Nanopore Flongle for detecting SARS-CoV-2 and other respiratory viruses in under two hours.

Insights into the salivary N-glycome of Lutzomyia longipalpis, vector of visceral leishmaniasis

This study characterizes the N-glycan profile of Lutzomyia longipalpis saliva, identifying oligomannose structures and a novel 144 Da modification.

Accelerating Monte Carlo modeling of structured-light based diffuse optical imaging via "photon sharing"

This paper introduces an efficient Monte Carlo method for simulating spatially modulated light transport in 3D domains, achieving significant speedups in both forward and inverse problems.

Gut dysbiosis protects against liver injury in autophagy deficient mice by FXR-FGF15 feedback signaling

This study shows that gut dysbiosis reduces liver injury in autophagy-deficient mice through FXR-FGF15 signaling, suggesting caution in antibiotic use during liver disease.

Effects of High-Grain Diet with Buffering Agent on the Milk Protein Synthesis in Lactating Goats

This study examines how a high-grain diet with a buffering agent affects amino acid levels in the blood and milk protein synthesis in lactating goats, finding increased amino acid concentrations and mTOR pathway activation.