Author

J. E. James

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Evolutionary Biology· 5

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Approach:statistical model· 5 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Research Focus:protein folding & dynamics· 2 Assay:protein sequence· 2 Organism:rat· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

J. Masel· 3 shared A. L. Wheeler· 2 shared C. Weibel· 2 shared A. J. Coffman· 1 shared A. L. Fortier· 1 shared A. P. Ragsdale· 1 shared C. A. Weibel· 1 shared C. D. Jiggins· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersEvolutionary Biology

J. Masel

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5 papers

Recent·Most cited

The protein domains of vertebrate species in which selection is more effective have greater intrinsic structural disorder

C. Weibel, A. L. Wheeler, J. E. James, S. Willis, H. McShea, J. Masel

The paper introduces a new Codon Adaptation Index (CAIS) to measure selection effectiveness in vertebrates and shows that more adapted species have protein domains with higher intrinsic structural disorder.

bioRxiv · Mar 2, 2023Evolutionary Biology

The effectiveness of selection in a species affects the direction of amino acid frequency evolution

H. S. McShea, A. L. Wheeler, P. Goodman, C. A. Weibel, S. Wehbi, J. E. James, G. A. Huttley, J. Masel

The paper examines how effective selection in species influences amino acid frequency evolution, finding that preferred amino acids are less costly to synthesize and use GC-rich codons, explaining 85% of variance in preferences.

bioRxiv · Feb 1, 2023 · PreprintEvolutionary Biology

Inferring genome-wide correlations of mutation fitness effects between populations

X. Huang, A. L. Fortier, A. J. Coffman, T. J. Struck, M. N. Irby, J. E. James, J. E. Burguette, A. P. Ragsdale, R. N. Gutenkunst

The paper develops a method to infer genome-wide correlations of mutation fitness effects between populations and finds that these correlations are inversely related to genetic differentiation.

bioRxiv · Feb 18, 2021Evolutionary Biology

Universal and taxon-specific trends in protein sequences as a function of age

J. E. James, S. M. Willis, P. G. Nelson, C. Weibel, L. J. Kosinski, J. Masel

The paper analyzes protein sequence trends across species age, finding universal hydrophobic clustering reduction but taxon-specific structural disorder patterns in young domains.

bioRxiv · Mar 26, 2020Evolutionary Biology

Classic and introgressed selective sweeps shape mimicry loci across a butterfly adaptive radiation

M. Moest, S. M. Van Belleghem, J. E. James, C. Salazar, S. H. Martin, S. L. Barker, G. R. P. Moreira, C. Merot, M. Joron, N. J. Nadeau, F. M. Steiner, C. D. Jiggins

The paper analyzes genome sequences from Heliconius butterflies to show selection on color pattern loci, identifying both classic and introgressed selective sweeps.

bioRxiv · Jun 28, 2019Evolutionary Biology