The effectiveness of selection in a species affects the direction of amino acid frequency evolution
H. S. McShea, A. L. Wheeler, P. Goodman, C. A. Weibel, S. Wehbi, J. E. James, G. A. Huttley, J. Masel
The paper examines how effective selection in species influences amino acid frequency evolution, finding that preferred amino acids are less costly to synthesize and use GC-rich codons, explaining 85% of variance in preferences.
bioRxiv · Feb 1, 2023 · PreprintEvolutionary Biology