BiochemistrybioRxiv
A Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling
A. L. George, F. R. Sidgwick, J. E. Watt…·M. E. Duenas
This study compares DIA-based label-free quantification methods with TMT-DDA for thermal proteome profiling, finding DIA approaches are comparable or better for detecting drug target engagement.
DOI 10.1021/acs.jproteome.3c00111