Author

J. Eichorst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Research Focus:cell signaling & trafficking· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:spatial domain detection· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

C. Beppler· 2 shared E. Cai· 2 shared K. Marchuk· 2 shared M. F. Krummel· 2 shared C. A. Castellanos· 1 shared K. T. Roybal· 1 shared V. Sriram· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

C. Beppler

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2 papers

Recent·Most cited

T cells use distinct topological and membrane receptor scanning strategies that individually coalesce during receptor recognition

E. Cai, C. Beppler, J. Eichorst, K. Marchuk, M. F. Krummel

This study shows T cells use independent scanning strategies for microvilli and receptor patches, which coalesce during receptor recognition.

bioRxiv · Feb 23, 2022 · PreprintImmunology

Visualizing and manipulating hyperstabilization of T cell microvilli contacts by engineered chimeric antigen receptors

C. Beppler, J. Eichorst, K. Marchuk, E. Cai, C. A. Castellanos, V. Sriram, K. T. Roybal, M. F. Krummel

This study uses advanced imaging to show that engineered CARs with high affinity hyperstabilize T cell microvilli contacts, impairing function, while reducing affinity restores normal dynamics and improves effector function.

bioRxiv · Aug 18, 2021Immunology