Author

C. Beppler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:imaging· 3 Research Focus:cell signaling & trafficking· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:spatial domain detection· 1

Frequent Co-Authors

E. Cai· 3 shared K. Marchuk· 3 shared M. F. Krummel· 3 shared J. Eichorst· 2 shared A. M. Mujal· 1 shared C. A. Castellanos· 1 shared D. Nam· 1 shared E. W. Roberts· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

E. Cai

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

T cells use distinct topological and membrane receptor scanning strategies that individually coalesce during receptor recognition

E. Cai, C. Beppler, J. Eichorst, K. Marchuk, M. F. Krummel

This study shows T cells use independent scanning strategies for microvilli and receptor patches, which coalesce during receptor recognition.

bioRxiv · Feb 23, 2022 · PreprintImmunology

Visualizing and manipulating hyperstabilization of T cell microvilli contacts by engineered chimeric antigen receptors

C. Beppler, J. Eichorst, K. Marchuk, E. Cai, C. A. Castellanos, V. Sriram, K. T. Roybal, M. F. Krummel

This study uses advanced imaging to show that engineered CARs with high affinity hyperstabilize T cell microvilli contacts, impairing function, while reducing affinity restores normal dynamics and improves effector function.

bioRxiv · Aug 18, 2021Immunology

Tumors Exploit Dedicated Intracellular Vesicles to Program T cell Responses

E. W. Roberts, M. K. Ruhland, E. Cai, A. M. Mujal, K. Marchuk, C. Beppler, D. Nam, N. K. Serwas, M. Binnewies, M. F. Krummel

The paper shows myeloid cells transfer tumor antigen-laden vesicles to APCs, directing T cell responses away from memory phenotypes.

bioRxiv · Jul 4, 2019 · PreprintImmunology