E. Cai

Deep learning reveals functional archetypes in the adult human gut microbiome that underlie interindividual variability and confound disease signals

The paper uses deep learning to identify three functional archetypes in the adult human gut microbiome, revealing their roles in interindividual variability and disease associations.

Renalase inhibition regulates β cell metabolism to defend against acute and chronic stress

This study shows that inhibiting Renalase protects β cells from stress by shifting metabolism towards glycolysis and GSH synthesis in both mice and humans.

Cilium proteomics reveals Numb as a positive regulator of the Hedgehog signaling pathway

This study identifies Numb as a ciliary protein that promotes Hedgehog signaling by facilitating Ptch1 exit from the cilium through endocytic mechanisms.

T cells use distinct topological and membrane receptor scanning strategies that individually coalesce during receptor recognition

This study shows T cells use independent scanning strategies for microvilli and receptor patches, which coalesce during receptor recognition.

Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer

This study investigates the interaction between macrophages and exhausted CD8+ T cells in the tumor microenvironment, showing they form a feedback loop that promotes tumor survival.

Visualizing and manipulating hyperstabilization of T cell microvilli contacts by engineered chimeric antigen receptors

This study uses advanced imaging to show that engineered CARs with high affinity hyperstabilize T cell microvilli contacts, impairing function, while reducing affinity restores normal dynamics and improves effector function.

Standardized quality control workflow to evaluate the reproducibility and differentiation potential of human iPSCs into neurons

The paper establishes a standardized quality control workflow to assess variability and reproducibility of human iPSCs in differentiation into neurons and other germ layers.

Tumors Exploit Dedicated Intracellular Vesicles to Program T cell Responses

The paper shows myeloid cells transfer tumor antigen-laden vesicles to APCs, directing T cell responses away from memory phenotypes.

Single-molecule tracking in live Yersinia enterocolitica reveals distinct cytosolic complexes of injectisome subunits

The paper uses single-molecule tracking to show SctQ and SctL form stable cytosolic complexes, revealing dynamic regulatory mechanisms in type 3 secretion.