The mechanism of RNA capping by SARS-CoV-2
G. J. Park, A. Osinski, G. Hernandez, J. Eitson, A. Majumdar, M. Tonelli, K. Henzler-Wildman, K. Pawlowski, Z. Chen, Y. Li, J. Schoggins, V. S. Tagliabracci
This study reveals how SARS-CoV-2 caps its RNA genome through an unconventional mechanism involving RNAylation and methyltransferase activity, identifying potential antiviral targets.
bioRxiv · Feb 7, 2022Biochemistry