G. Hernandez

Multimodal delineation of a layer of effector function among exhausted CD8 T cells in tumors

The paper identifies a potent effector state among exhausted CD8 T cells in tumors using multimodal CITE-Seq, showing enhanced cytokine production and tumor-killing ability.

Role of BicDR in bristle shaft construction, tracheal development, and support of BicD functions

This study investigates BicDR's role in bristle shaft construction, tracheal development, and its interaction with BicD in cargo transport and actin cytoskeleton organization.

Fic-mediated AMPylation tempers the Unfolded Protein Response during physiological stress

This study shows that Fic-mediated AMPylation regulates the UPR response in the pancreas during stress, preventing excessive inflammation and damage.

The mechanism of RNA capping by SARS-CoV-2

This study reveals how SARS-CoV-2 caps its RNA genome through an unconventional mechanism involving RNAylation and methyltransferase activity, identifying potential antiviral targets.

MgrB dependent colistin resistance in Klebsiella pneumoniae is associated with an increase in host-to-host transmission.

This study shows that MgrB-dependent colistin resistance in K. pneumoniae reduces gut colonization but increases survival outside the host, enhancing transmission.

PU.1 expression defines distinct functional activities in the phenotypic HSC compartment in a mouse model of inflammatory stress

The paper shows that PU.1 expression levels in phenotypic HSCs define distinct functional activities under steady-state and inflammatory conditions.

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis

The paper shows pre-neoplastic stromal cells promote BRCA1-driven breast cancer by inducing epithelial proliferation and altering differentiation.

The pathogen-encoded signaling receptor Tir exploits host-like intrinsic disorder to assist infection

This paper identifies Tir as a disordered protein that mimics host immune receptors to facilitate bacterial infection by modulating host processes.

Transcription factor PU.1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress

This study shows that PU.1 enforces HSC quiescence by repressing protein synthesis and cell cycle genes, preventing clonal expansion during inflammatory stress.

The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

This study examines SARS-CoV-2 neutralizing and infection-enhancing antibodies, showing in vitro enhancement does not always lead to in vivo disease enhancement, but can cause increased lung inflammation in monkeys.

Lipid nanoparticle encapsulated nucleoside-modified mRNA vaccines elicit polyfunctional HIV-1 antibodies comparable to proteins in nonhuman primates

This study compares the immunogenicity of mRNA-LNP vaccines to protein vaccines in nonhuman primates, finding comparable or superior HIV-1 antibody responses.

Dopaminergic mechanisms underlying the expression of antipsychotic-induced dopamine supersensitivity in rats

This study investigates how dopaminergic mechanisms in rats mediate antipsychotic-induced dopamine supersensitivity, finding differential roles for D1 and D2 receptors in modulating behavioral responses to d-amphetamine.

Representative diatom and coccolithophore species exhibit divergent responses throughout simulated upwelling cycles

This study compares how diatoms and coccolithophores respond to simulated upwelling cycles, showing diatoms can rapidly adjust growth and nitrate assimilation under changing light and nutrient conditions.

The basolateral nucleus of the amygdala regulates both the predictive and incentive motivational properties of reward cues

This study shows that basolateral amygdala (BLA) activity enhances both the predictive and incentive motivational properties of reward cues in rats.

Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

This study identifies unique molecular features of MDSCs using single-cell transcriptomics, revealing a distinct maturation trajectory and novel surface markers for their detection.