Cell BiologybioRxiv
Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate
E. Prieto-Fernandez, L. Egia-Mendikute, L. Vila-Vecilla…·A. Palazon
This study shows hypoxia reduces SARS-CoV-2 spike protein attachment to epithelial cells by lowering ACE2, NRP1, and HS levels, suggesting hypoxia may limit infection.
DOI 10.1080/22221751.2021.1932607