Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.
J. Gopalan, M. Omar, A. Roy, N. M. Cruz, J. Falcone, K. Forbush, J. Himmelfarb, B. Freedman, J. D. Scott
The paper shows that targeting the AKAP220-PPI-HDAC6 pathway restores renal ciliary homeostasis in ADPKD models by modulating actin dynamics and cilia development.
bioRxiv · Feb 24, 2021Cell Biology