Cell BiologybioRxiv
Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.
J. Gopalan, M. Omar, A. Roy…·J. D. Scott
The paper shows that targeting the AKAP220-PPI-HDAC6 pathway restores renal ciliary homeostasis in ADPKD models by modulating actin dynamics and cilia development.