Author

J. D. Scott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

F. D. Smith· 2 shared H. L. Kenerson· 2 shared K. Forbush· 2 shared R. S. Yeung· 2 shared A. B. Francisco· 1 shared A. Bhat· 1 shared A. P. Massa· 1 shared A. Roy· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCancer Biology

F. D. Smith

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma

S. M.-L. Lauer, M. H. Omar, M. G. Golkowski, H. L. Kenerson, B. C. Pascual, K. Forbush, F. D. Smith, J. Gordan, S.-E. M. Ong, R. S. Yeung, J. D. Scott

This study identifies BAG2 as a key player in DNAJ-PKAc-mediated chemotherapeutic resistance in fibrolamellar carcinoma by linking it to Hsp70 and Bcl-2.

bioRxiv · Jun 28, 2023Cancer Biology

Oncogenic PKA signaling stabilizes MYC oncoproteins via an aurora kinase A-dependent mechanism

G. K. L. Chan, S. Maisel, Y. C. Hwang, R. R. B. Wolber, P. Vu, K. C. Patra, M. Bouhaddou, H. L. Kenerson, R. S. Yeung, D. L. Swaney, N. J. Krogan, R. E. Turnham, J. D. Scott, K. J. Riehle, N. Bardeesy, J. D. Gordan

This study identifies two PKA-driven oncogenic mechanisms, showing AURKA stabilizes MYC oncoproteins through a PIM2-mediated feedback loop, and suggests CD-532 as a potential therapeutic target.

bioRxiv · Apr 16, 2021Cancer Biology

Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis.

J. Gopalan, M. Omar, A. Roy, N. M. Cruz, J. Falcone, K. Forbush, J. Himmelfarb, B. Freedman, J. D. Scott

The paper shows that targeting the AKAP220-PPI-HDAC6 pathway restores renal ciliary homeostasis in ADPKD models by modulating actin dynamics and cilia development.

bioRxiv · Feb 24, 2021Cell Biology

Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles

P. J. Bucko, I. Garcia, R. Manocha, A. Bhat, L. Wordeman, J. D. Scott

This study shows that Gravin coordinates γ-tubulin organization during mitosis by regulating local Plk1 signaling at spindle poles.

bioRxiv · Jun 12, 2020Cell Biology

Hotspots of aberrant enhancer activity in fibrolamellar carcinoma reveal molecular mechanisms of oncogenesis and intrinsic drug resistance

T. A. Dinh, R. Sritharan, F. D. Smith, A. B. Francisco, R. K. Ma, R. P. Bunaciu, M. Kanke, C. G. Danko, A. P. Massa, J. D. Scott, P. Sethupathy

This study identifies aberrant enhancer activity in fibrolamellar carcinoma, revealing molecular mechanisms of oncogenesis and drug resistance, and suggests new therapeutic targets.

bioRxiv · Jan 18, 2020 · PreprintCancer Biology