BiophysicsbioRxiv
Molecular basis of polyspecific drug binding and transport by OCT1 and OCT2
Y. Suo, N. J. Wright, H. Guterres…·S.-Y. Lee
The paper presents cryo-EM structures of OCT1 and OCT2 in different states and combines them with functional experiments to reveal principles of organic cation recognition and the alternating access mechanism.
DOI 10.1038/s41594-023-01017-4