Metal-Organic Framework Encapsulated Whole-Cell Vaccines Enhance Humoral Immunity against Bacterial Infection
M. A. Luzuriaga, F. C. Herbert, O. Brohlin, J. Gadhvi, T. Howlett, A. Shahrivarkevishahi, Y. H. Wijesundara, S. Venkitapathi, K. Veera, R. Ehrman, C. E. Benjamin, S. Popal, M. D. Burton, M. A. Ingersoll, N. J. De Nisco, J. J. Gassensmith
This paper demonstrates a method to enhance the immunogenicity of E. coli by encapsulating it in a metal-organic framework, leading to improved antibody production and survival in a mouse model.
bioRxiv · Jun 14, 2020 · PreprintImmunology