Dietary Pyruvate Targets Cytosolic Phospholipase A2 to Mitigate Inflammation and Obesity in Mice
S. Hasan, N. Ghani, X. Zhao, J. Good, A. Huang, H. L. Wrona, J. Liu, C. Liu
This study identifies pyruvate as an inhibitor of cPLA2 that reduces obesity and inflammation in mice by targeting this enzyme, suggesting its potential as a therapeutic agent.
bioRxiv · Sep 7, 2023Cell Biology