A. Huang

Freeform robotic optical coherence tomography beyond the optical field-of-view limit

This paper introduces a freeform robotic OCT system to overcome the FOV limitation in imaging non-planar anatomies, demonstrating its application in imaging the mouse eye's aqueous humor outflow pathway.

Worldwide study of the taste of bitter medicines and their modifiers

This study examines bitterness perception of medicines and modifiers across diverse ancestries, finding ancestry-related differences in bitterness ratings and genetic associations with taste sensitivity.

A sequence- and structure-based characterization of microbial enzymes identifies P. stutzeri as a plastic-degrading species

The paper identifies Pseudomonas stutzeri as a plastic-degrading species by analyzing microbial enzyme sequences and structures, and validates its ability to degrade synthetic polymers.

Detection of clade 2.3.4.4b highly pathogenic H5N1 influenza virus in New York City

The paper detects H5N1 clade 2.3.4.4b influenza viruses in urban birds in New York City and highlights the urban animal-human interface as a potential zoonotic risk.

Discovery of Alkenyl Oxindole as a Novel PROTAC Moiety for Targeted Protein Degradation via CRL4DCAF11 Recruitment

The paper develops JQ1-alkenyl oxindole conjugates that degrade BRD4 via the ubiquitin-proteasome system and recruits CRL4DCAF11, identifying HL435 as a potent antitumor lead.

Degradation of indole-3-acetic acid by plant-associated microbes

This study identifies bacterial isolates capable of degrading indole-3-acetic acid (IAA) from Arabidopsis and rice roots, revealing their functional roles and association with IAA producers.

Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation

MATCHY quantifies cell adhesion and traction in primary kidney cells, revealing an energetic ratchet mechanism driving nephron condensation during differentiation.

Rho/ROCK activity tunes cell compartment segregation and differentiation in nephron-forming niches

This study shows that Rho/ROCK inhibition enhances mixing between nephron progenitor and stromal cells, increasing nephrogenesis in kidney organoids.

Direct measures of liking and intensity of taste, smell, and chemesthetic stimuli are similar between young people reporting they did or did not have COVID-19

This study finds no difference in taste and smell intensity or liking between young people with and without a history of COVID-19.

Modeling Cystic Fibrosis Chronic Infection Using Engineered Mucus-like Hydrogels

This study develops mucus-like hydrogels to model cystic fibrosis airway infections and finds that antibiotic resistance depends on both hydrogel properties and culture conditions.

Dietary Pyruvate Targets Cytosolic Phospholipase A2 to Mitigate Inflammation and Obesity in Mice

This study identifies pyruvate as an inhibitor of cPLA2 that reduces obesity and inflammation in mice by targeting this enzyme, suggesting its potential as a therapeutic agent.

Thiazolidinediones are partially effective bitter blockers

This study evaluates the effectiveness of thiazolidinediones (TZDs) as bitter blockers by testing their ability to reduce bitterness of TAF and PRAZ in two taste panels.

Comparative single-nucleus RNA-seq analysis captures shared and distinct responses to beneficial and pathogenic microbes in roots

The paper uses single-nucleus RNA-seq to compare plant root responses to beneficial and pathogenic microbes, identifying triterpene biosynthesis as a novel response to pathogens.

ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes

This study uses human heart organoids to show that pregestational diabetes causes ER stress and lipid imbalance, leading to cardiomyopathy, and identifies potential therapeutic targets.

A patterned human heart tube organoid model generated by pluripotent stem cell self-assembly

This paper develops a patterned human heart tube organoid model using pluripotent stem cell self-assembly, showing anterior-posterior patterning and multiple cardiac cell types.

Roots fuel cell produces and stores clean energy

This study demonstrates that plant roots release redox species that generate electricity in a bio-fuel cell, with light enhancing the current and roots enabling energy storage.

Extreme sex chromosome differentiation, likely driven by inversion, contrasts with mitochondrial paraphyly between species of crowned sparrows

The paper examines genomic differentiation between sympatric sparrow species, finding extreme sex chromosome differentiation driven by inversion, contrasting with mitochondrial paraphyly.

Tubule jamming in the developing mouse kidney creates cyclical mechanical stresses in nephron-forming niches

The paper investigates how crowding in developing mouse kidney tubules creates mechanical stresses in nephron-forming niches, revealing how spatial constraints influence branching and nephron formation.

Chemical genetic screening identifies nalacin as an inhibitor of GH3 amido synthetase for auxin conjugation

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

Extensive neutralization against SARS-CoV-2 variants elicited by Omicron-specific subunit vaccine booster

This study shows that an Omicron-specific subunit vaccine booster enhances neutralizing antibodies against SARS-CoV-2 variants and the ancestral virus, with a two-dose WT-RBD plus Omicron-RBD booster showing the strongest response.

The mycotoxin Beauvericin exhibits immunostimulatory effects on dendritic cells via activating the TLR4 signaling pathway

This study identifies Beauvericin as an activator of dendritic cells via the TLR4 signaling pathway, suggesting its potential as a vaccine adjuvant or cancer immunotherapy.

VRK1 is a Paralog Synthetic Lethal Target in VRK2-methylated Glioblastoma

This study identifies VRK1 as a synthetic lethal target in VRK2-methylated glioblastoma by showing that VRK1 inhibition leads to tumor growth inhibition in xenograft models.

Molecular probes of spike ectodomain and its subdomains for SARS-CoV-2 variants, Alpha through Omicron

The paper designs and produces molecular probes for SARS-CoV-2 variants to assess immune responses and isolate neutralizing antibodies.

HBV enveloped particle secretion is positively regulated by GRP78 through direct interaction with preS1

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.

Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

Characterization of SARS-CoV-2 variants B.1.617.1 (Kappa), B.1.617.2 (Delta) and B.1.618 on cell entry, host range, and sensitivity to convalescent plasma and ACE2 decoy receptor

This study characterizes SARS-CoV-2 variants Kappa, Delta, and B.1.618, finding increased ACE2 binding in non-human hosts, enhanced spike cleavage, and reduced neutralization sensitivity, but maintained sensitivity to ACE2 decoy receptor.

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

This study identifies the Y453F mutation in SARS-CoV-2 spike protein as enhancing binding to mink ACE2 while maintaining human ACE2 utilization, highlighting its role in host adaptation.

Reduced neutralization of SARS-CoV-2 B.1.617 variant by inactivated and RBD-subunit vaccine

The paper evaluates the neutralization efficacy of inactivated and RBD-subunit vaccines against SARS-CoV-2 B.1.617 and B.1.1.7 variants using a pseudovirus-based assay.

Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.