Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PLpro and Mpro in in vitro studies
M. Zmudzinski, W. Rut, K. Olech, J. Granda, M. Giurg, M. Burda-Grabowska, L. Zhang, X. Sun, Z. Lv, D. Nayak, M. Kesik-Brodacka, S. Olsen, R. Hilgenfeld, M. Drag
This study identifies ebselen derivatives as potent inhibitors of SARS-CoV-2 proteases PLpro and Mpro in vitro, with some compounds showing greater potency than ebselen itself.
bioRxiv · Aug 30, 2020 · PreprintBiochemistry