Z. Lv

mTORC1/S6K1 signaling promotes sustained oncogenic translation through modulating CRL3IBTK-mediated non-degradative ubiquitination of eIF4A1

O-GlcNAcylation of YTHDF2 antagonizes ERK-dependent phosphorylation and inhibits lung carcinoma

This study identifies O-GlcNAcylation of YTHDF2 at Thr-49 as a regulator of ERK-dependent phosphorylation and tumor growth in lung carcinoma.

Repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting

This study shows repeated Omicron exposures reduce immune imprinting from wildtype vaccines, leading to higher neutralizing antibodies against XBB variants.

Airway secretory cell-derived p63+ progenitors contribute to alveolar regeneration after sterile lung injury

Host-microbe interactions mediate doramectin-promoted metabolic reprogramming of CD8+ T-cells and amplify antitumor immunity

This study shows that doramectin promotes CD8+ T-cell metabolic reprogramming and antitumor immunity, mediated by gut microbiota interactions.

Cryo-EM complex structure of active GPR75 with a nanobody

The paper reports the Cryo-EM structure of active GPR75 with a nanobody, revealing its activation mechanism and providing a structural basis for anti-obesity drug discovery.

Development of Equine Polyclonal Antibodies as a Broad-Spectrum Therapy Against SARS-CoV-2 Variants

This paper develops equine polyclonal antibodies that broadly neutralize major SARS-CoV-2 variants, showing high efficacy in vitro and ex vivo with low cost and potential for large-scale production.

Screening of cell-virus, cell-cell, gene-gene interactions among kingdoms of life at single cell resolution

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

Viral receptor profiles of masked palm civet revealed by single-cell transcriptomics

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

ICER controls HIV-1 infection and replication in elite controllers

The paper identifies ICER as a host factor that contributes to HIV resistance in elite controllers by regulating HIV-1 replication through alternative splicing and promoter activity.

Double Lock of a Potent Human Monoclonal Antibody against SARS-CoV-2

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody

A potent neutralizing antibody protected against SARS-CoV-2 in an hACE2 mouse model by blocking viral receptor interaction.

Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PLpro and Mpro in in vitro studies

This study identifies ebselen derivatives as potent inhibitors of SARS-CoV-2 proteases PLpro and Mpro in vitro, with some compounds showing greater potency than ebselen itself.

Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design

This study profiles SARS-CoV-2-PLpro activity and determines inhibitor structures to guide anti-COVID-19 drug design.

Rapid development of an inactivated vaccine for SARS-CoV-2

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

Plastome phylogenomic study of Gentianeae (Gentianaceae): widespread gene tree discordance and its association with evolutionary rate heterogeneity of plastid genes

This study analyzes plastome sequences from Gentianeae to show gene tree discordance and evolutionary rate heterogeneity among plastid genes, suggesting the need for more nuanced phylogenomic approaches.

Exfoliated near infrared fluorescent CaCuSi4O10 nanosheets with ultra-high photostability and brightness for biological imaging

This paper develops exfoliated CaCuSi4O10 nanosheets with ultra-high near infrared fluorescence for biological imaging in animals and plants.

Spontaneous Self-assembly of Amyloid β (1-40) into Dimers

This study uses molecular dynamics simulations to show that Aβ(1-40) monomers form stable dimers through specific inter-peptide interactions, without forming long β-strands typical of fibrils.

KPNA2 promotes cellular proliferation and inhibits apoptosis in the Saos-2 osteosarcoma cell line

This study shows KPNA2 is highly expressed in osteosarcoma tissues and its reduction inhibits cell proliferation and promotes apoptosis in Saos-2 cells.