PIKfyve deficiency in myeloid cells impairs lysosomal homeostasis in macrophages and promotes systemic inflammation in mice
S. H. Min, A. Suzuki, L. Weaver, J. Guzman, L. Zhao, F. Gonzalez, L. A. Spruce, S. H. Seeholzer, E. M. Behrens, C. S. Abrams
This study shows that PIKfyve deficiency in myeloid cells impairs lysosomal function, leading to systemic inflammation and tissue infiltration in mice.
bioRxiv · Apr 16, 2019Cell Biology